The organic cotton makes a difference for me. I have other brands of sweatpants and these are for more comfortable on my skin! These are cozy and don't make my skin itch (as some synthetic fabrics do especially in the winter).
These are unisex, I am usually a womens' small ( 5'7''/~130lbs), I bought a small and they fit fine. Since they are unisex, the space between the top of the pant and where the pants splits in 2 legs is a little longer. I just wear them as somewhat high waisted to accomodate for the extra space. Overall I like the fit and comfort of the pants and may buy another pair in the future.